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consume omega-3 fatty acid and antioxidants—since telomeres are very sensitive to oxidation," relates Woynarowski. "Second, it's possible to improve telomeres' length by activating the enzyme that exists in all cells but gets turned off: telomerase." Telomerase lengthens telomeres and slows breakdown, and blocks the gene codes for aging. Woynarowski cites the supplement product TA65, owned by T.A. Sciences (tasciences.com), which purchased the rights to telomerase activator technology from biotech company Geron in 2002, as a breakthrough in this arena. TA-65 is currently the only telomerase activator that has supporting lab data on human subjects, and 8 to 10 years of data accumulated on humans, mice and cells. "TA-65 improves several biomarkers: insulin/glucose levels, oxidation levels and skin/bone/immune system health," Woynarowski says. But supplements aren't the only vehicle being explored. Anderson predicts that telomere-targeted strategies to slow the aging process will develop into pharmaceutical agents. In one study using mice, he notes, the botanical substance resveratrol, derived from the skins of grapes, appeared to increase telomerase and add the human equivalent of 10 to 15 years of life. Astragalus root is another ingredient being tested to increase telomerase. Meanwhile, topical products that target telomeres have started to roll out. However, as Anderson points out, cosmetics products are approved by the FDA only for safety—not for efficacy, as a pharmaceutical product would be tested. "Manufacturers are now looking at using these products for wound healing, but it's simply easier to get something to market as a cosmetic," he says. Certainly there is a great incentive to bring effective, topical telomerase-activating products to a beautyseeking public. In addition to shortening life span, deficient telomere lengths cause premature baldness and gray hair, and lead to poor skin healing. "Boosting telomeres even in those with normal lengths might postpone baldness or grayness, or keep skin younger or healthier," speculates Cawthon, "but no public studies have tested those with normal telomeres." He recommends treading cautiously with all topical products that make claims pertaining to telomeres. "I haven't yet seen any studies for applying products to the skin or scalp," he says. "It's a rational thing to try, but I'd wait for trials and results to be published first." Woynarowski agrees, and notes that although such products are safe and well-tolerated they're also pricey. "Telomeres are getting so popular that companies are using them to push their own agendas, so be careful about what you believe," he says. ® dayspamagazine.com/freeinfo • Use FreeInfo #31 dayspamagazine.com | JANUARY 2013 73